Quantitative adverse outcome pathway (qAOP) models for toxicity prediction
نویسندگان
چکیده
منابع مشابه
Adverse outcome pathway development II: best practices.
Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through develop...
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An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regula...
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Allergic sensitisation of the respiratory tract by chemicals is associated with rhinitis and asthma and remains an important occupational health issue. Although less than 80 chemicals have been confirmed as respiratory allergens the adverse health effects can be serious, and in rare instances can be fatal, and there are, in addition, related socioeconomic issues. The challenges that chemical re...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2020
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-020-02774-7